LEVODOPA-SENSITIVE, DYNAMIC CHANGES IN EFFECTIVE CONNECTIVITY DURING SIMULTANEOUS MOVEMENTS IN PARKINSON'S DISEASE
Identifieur interne : 002088 ( Main/Exploration ); précédent : 002087; suivant : 002089LEVODOPA-SENSITIVE, DYNAMIC CHANGES IN EFFECTIVE CONNECTIVITY DURING SIMULTANEOUS MOVEMENTS IN PARKINSON'S DISEASE
Auteurs : S. J. Palmer [Canada] ; L. Eigenraam [Canada] ; T. Hoque [Canada] ; R. G. Mccaig [Canada] ; A. Troiano [Canada] ; M. J. Mckeown [Canada]Source :
- Neuroscience [ 0306-4522 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Brain (blood supply), Brain (drug effects), Brain (physiopathology), Brain Mapping, Case-Control Studies, Female, Functional Laterality, Functional imaging, Hand Strength, Humans, Image Processing, Computer-Assisted (methods), Levodopa, Levodopa (pharmacology), Levodopa (therapeutic use), Magnetic Resonance Imaging (methods), Male, Middle Aged, Models, Biological, Movement (drug effects), Nonlinear Dynamics, Nuclear magnetic resonance imaging, Oxygen (blood), Parkinson Disease (drug therapy), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Psychomotor Performance (drug effects), Psychomotor Performance (physiology).
- MESH :
- chemical , blood : Oxygen.
- chemical , pharmacology : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- blood supply : Brain.
- drug effects : Brain, Movement, Psychomotor Performance.
- drug therapy : Parkinson Disease.
- methods : Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- pathology : Parkinson Disease.
- physiology : Psychomotor Performance.
- physiopathology : Brain, Parkinson Disease.
- Aged, Analysis of Variance, Brain Mapping, Case-Control Studies, Female, Functional Laterality, Hand Strength, Humans, Male, Middle Aged, Models, Biological, Nonlinear Dynamics.
Abstract
Changes in effective connectivity during the performance of a motor task appear important for the pathogenesis of motor symptoms in Parkinson's disease (PD). One type of task that is typically difficult for individuals with PD is simultaneous or bimanual movement, and here we investigate the changes in effective connectivity as a potential mechanism. Eight PD subjects off and on L-DOPA medication and 10 age-matched healthy control subjects performed both simultaneous and unimanual motor tasks in an fMRI scanner. Changes in effective connectivity between regions of interest (ROIs) during simultaneous and unimanual task performance were determined with structural equation modeling (SEM), and changes in the temporal dynamics of task performance were determined with multivariate autoregressive modeling (MAR). PD subjects demonstrated alterations in both effective connectivity and temporal dynamics compared with control subjects during the performance of a simultaneous task. L-DOPA treatment was able to partially normalize effective connectivity and temporal patterns of activity in PD, although some connections remained altered in PD even after medication. Our results suggest that difficulty performing simultaneous movements in PD is at least in part mediated by a disruption of effective communication between widespread cortical and subcortical areas, and L-DOPA assists in normalizing this disruption. These results suggest that even when the site of neurodegeneration is relatively localized, study of how disruption in a single region affects connectivity throughout the brain can lead to important advances in the understanding of the functional deficits caused by neurodegenerative disease.
Affiliations:
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J." last="Palmer">S. J. Palmer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, University of British Columbia, M36 Purdy Pavilion, 2221 Wesbrook Mall</s1><s2>Vancouver, BC, V6T 2B5</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC, V6T 2B5</wicri:noRegion></affiliation></author><author><name sortKey="Eigenraam, L" sort="Eigenraam, L" uniqKey="Eigenraam L" first="L." last="Eigenraam">L. Eigenraam</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, BC</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC</wicri:noRegion></affiliation></author><author><name sortKey="Hoque, T" sort="Hoque, T" uniqKey="Hoque T" first="T." last="Hoque">T. Hoque</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, BC</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC</wicri:noRegion></affiliation></author><author><name sortKey="Mccaig, R G" sort="Mccaig, R G" uniqKey="Mccaig R" first="R. G." last="Mccaig">R. G. Mccaig</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, BC</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC</wicri:noRegion></affiliation></author><author><name sortKey="Troiano, A" sort="Troiano, A" uniqKey="Troiano A" first="A." last="Troiano">A. Troiano</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, BC</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC</wicri:noRegion></affiliation></author><author><name sortKey="Mckeown, M J" sort="Mckeown, M J" uniqKey="Mckeown M" first="M. J." last="Mckeown">M. J. Mckeown</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, University of British Columbia, M36 Purdy Pavilion, 2221 Wesbrook Mall</s1><s2>Vancouver, BC, V6T 2B5</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC, V6T 2B5</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Pacific Parkinson's Research Centre, University of British Columbia</s1><s2>Vancouver, BC</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Faculty of Medicine (Neurology), University of British Columbia</s1><s2>Vancouver, BC</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience</title><title level="j" type="abbreviated">Neuroscience</title><idno type="ISSN">0306-4522</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Antiparkinson Agents (pharmacology)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Brain (blood supply)</term><term>Brain (drug effects)</term><term>Brain (physiopathology)</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Female</term><term>Functional Laterality</term><term>Functional imaging</term><term>Hand Strength</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Levodopa</term><term>Levodopa (pharmacology)</term><term>Levodopa (therapeutic use)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Models, Biological</term><term>Movement (drug effects)</term><term>Nonlinear Dynamics</term><term>Nuclear magnetic resonance imaging</term><term>Oxygen (blood)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Psychomotor Performance (drug effects)</term><term>Psychomotor Performance (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term><term>Movement</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Brain Mapping</term><term>Case-Control Studies</term><term>Female</term><term>Functional Laterality</term><term>Hand Strength</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Models, Biological</term><term>Nonlinear Dynamics</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Lévodopa</term><term>Imagerie RMN</term><term>Imagerie fonctionnelle</term><term>Maladie de Parkinson</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Changes in effective connectivity during the performance of a motor task appear important for the pathogenesis of motor symptoms in Parkinson's disease (PD). One type of task that is typically difficult for individuals with PD is simultaneous or bimanual movement, and here we investigate the changes in effective connectivity as a potential mechanism. Eight PD subjects off and on L-DOPA medication and 10 age-matched healthy control subjects performed both simultaneous and unimanual motor tasks in an fMRI scanner. Changes in effective connectivity between regions of interest (ROIs) during simultaneous and unimanual task performance were determined with structural equation modeling (SEM), and changes in the temporal dynamics of task performance were determined with multivariate autoregressive modeling (MAR). PD subjects demonstrated alterations in both effective connectivity and temporal dynamics compared with control subjects during the performance of a simultaneous task. L-DOPA treatment was able to partially normalize effective connectivity and temporal patterns of activity in PD, although some connections remained altered in PD even after medication. Our results suggest that difficulty performing simultaneous movements in PD is at least in part mediated by a disruption of effective communication between widespread cortical and subcortical areas, and L-DOPA assists in normalizing this disruption. These results suggest that even when the site of neurodegeneration is relatively localized, study of how disruption in a single region affects connectivity throughout the brain can lead to important advances in the understanding of the functional deficits caused by neurodegenerative disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Palmer, S J" sort="Palmer, S J" uniqKey="Palmer S" first="S. J." last="Palmer">S. J. Palmer</name></noRegion><name sortKey="Eigenraam, L" sort="Eigenraam, L" uniqKey="Eigenraam L" first="L." last="Eigenraam">L. Eigenraam</name><name sortKey="Hoque, T" sort="Hoque, T" uniqKey="Hoque T" first="T." last="Hoque">T. Hoque</name><name sortKey="Mccaig, R G" sort="Mccaig, R G" uniqKey="Mccaig R" first="R. G." last="Mccaig">R. G. Mccaig</name><name sortKey="Mckeown, M J" sort="Mckeown, M J" uniqKey="Mckeown M" first="M. J." last="Mckeown">M. J. Mckeown</name><name sortKey="Mckeown, M J" sort="Mckeown, M J" uniqKey="Mckeown M" first="M. J." last="Mckeown">M. J. Mckeown</name><name sortKey="Mckeown, M J" sort="Mckeown, M J" uniqKey="Mckeown M" first="M. J." last="Mckeown">M. J. Mckeown</name><name sortKey="Troiano, A" sort="Troiano, A" uniqKey="Troiano A" first="A." last="Troiano">A. Troiano</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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